date:Aug 10, 2012
to slow the metabolism of other drugs), or sirolimus plus grapefruit juice.
They team enrolled 138 patients with incurable cancer and no known effective therapy.
Initially patients taking only sirolimus were given very low doses with the amounts gradually increasing as the study progressed. This was done to see how much of the drug was required to reach targeted levels, say the authors, who noted that they wanted to ensure that patients got the greatest anti-cancer effect with the fewest sid